Figure 24.10. Stereochemistry
of Proton Addition. In a transaminase active site, the addition of a
proton from the lys 20220k1016u ine residue to the bottom face of the quinonoid intermediate
determines the l configuration of the amino acid
product. The conserved arginine residue interacts with the a-carboxylate group and
helps establish the appropriate geometry of the quinonoid intermediate.
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